奥硝唑治疗口腔颌面部厌氧菌感染的对比观察

The clinical investigation of the efficacy of ornidazole against acute anaerobic infections

目的 评价奥硝唑治疗口腔颌面部厌氧菌感染的临床疗效及其安全性。方法 45例厌氧菌感染病例随机分为实验组 2 2例 ,应用奥硝唑治疗 .对照组 2 3例应用甲硝唑治疗 ,用药量均为每日 10 0 0mg ,分两次静脉滴注 ,疗程 5～ 10d ,对比观察两组的临床疗效、副反应和厌氧菌清除率。结果 40例可评估病人 ,奥硝唑与甲硝唑治疗急性厌氧菌感染总有效率分别为 85 %和 80 % ;细菌清除率分别为 84.2 1%和 68.42 % ;不良反应发生率分别为 18.18%和 3 0 .43 %。结论 奥硝唑治疗口腔颌面部急性厌氧菌感染安全有效 ,不良反应少 ,优于同类药物甲硝唑。

Objective To analyze and estimate the efficiency of ornidazole tha t have application in the anaerobic infection of oral and maxillofacical. Method 45 case of anaerobic infection in oral and maxillofacical were randomly divi ded into two groups, 22 cases treated with Orinidazole were enrolled in the stud y group, and 23 cases treated with Metronidazole served as control group. Result The effective rates of two groups were 85% and 80% respectively, and the clea rance rate of anaerobic bacteria were 84.21% and 68.42% respectively, Showing st atistically significant difference (p<0.05). The side effect accounted for 18.18 % and 30.43% respectively, Showing statistically significant difference (p<0.05) . Conclusion Orinidazole is effective and safe for treament of anaerobic infec tion.