摘要
①目的 探讨抗心磷脂抗体 (ACL)与冠心病 (CHD)发病的关系。②方法 采用ELISA法检测了1 0 0例CHD病人和 4 4例健康体检者血清ACL的变化 ,并计算ACL的平均结合指数 (BI)及其阳性率。 1 0 0例CHD病人中急性心肌梗死 (AMI) 1 8例 ,陈旧性心肌梗死 (OMI) 1 9例 ,不稳定性心绞痛 (UAP) 2 2例 ,稳定性心绞痛 (SA)4 1例。③结果 CHD病人ACL平均结合指数明显增高 ,与对照组比较 ,差异有显著性 (t=2 .5 2 9～ 3.92 1 ,P <0 .0 5 )。CHD病人 (包括AMI、OMI、UAP、SA病人 )的IgG ACL、IgM ACL、IgA ACL阳性率分别为 2 4 .0 %、1 8.0 %、6 .0 % ,而对照组均阴性 ,两者比较差异有显著性 (χ2 =9.0 5 1～ 1 1 2 .6 72 ,P <0 .0 1 )。AMI病人的IgG ACL、IgM ACL阳性率分别为 5 5 .5 %和 4 4 .4 % ,明显高于UAP和SA病人 (χ2 =4 .5 4 7～ 8.6 2 9,P <0 .0 5 )。④结论 CHD病人ACL明显异常 ,且与病情变化有关。
Objective\ To study the correlation between anticardiolipin antibodies(ACL) and the mechanism of coronary heart disease( CHD).\ Methods\ The levels of serum ACL were detected by enzyme linked immunosorbent assay(ELISA) in 100 patients with CHD, which included 18 patients with AMI, 19 patients with OMI, 22 patients with UAP and 41 patients with SA and 44 healthy subjects. The median bound indexes and positive rates were computed.\ Results\ The median bound indexes of ACL were significantly elevated in patients with CHD and differed significantly compared with healthy control group( t=2.529- 3.921 ,P <0.05). The positive rates of IgG ACL, IgM ACL and IgA ACL in patients with CHD were 24.0%,18.0%,6.0% respectively, but there was no positive case found in the control group, the difference was significant between them( χ 2=9.051- 112.672 , P <0.01).The positive rates of IgG ACL, IgM ACL in patients with AMI were 55.5% and 44.4% respectively, which elevated significantly than those with UAP and SA ( χ 2=4.547-8.629, P <0.05). \ Conclusion\ The levels of serum ACL were obviously abnormal in patients with CHD and associated with changes of patients conditions. Investigating the levels of ACL in patients with CHD would be helpful to forecast the pathological changes of CHD and prevent UAP from developing into AMI.
出处
《青岛大学医学院学报》
CAS
2003年第2期171-172,174,共3页
Acta Academiae Medicinae Qingdao Universitatis
