摘要
DNA的图形编码是在几何意义下,在不同位置,用不同的标记符号及不同的方向线段,对DNA的序列进行编码。DNA图形编码相对于DNA的字符编码而言,具有直观、简明、形象和便于比较局部DNA序列的相似性等特点。在分析已知各类DNA的图形表示模式的基础上,提出一种DNA序列的“双符三阶”图形编码,并以此对一些特异DNA编码序列进行分析。DNA图形编码与DNA字符编码呈一一对应关系,具有简便易行、编译方便、形象丰富、便于比较等优点。适用于DNA短序列的相似性检测与分析,在生物信息学上有一定的应用前景。
The graphic coding of DNA sequence is the geometric representation of DNA sequences by means of different notes and line segments in different positions. The letter coding (C?T?A?G) of DNA is the most fundamental representation of DNA sequence for information storage, comparision and analyzing of the gene data. But as compared to the DNA letter coding, the DNA graphic coding is more intuitive, direct visualizing and more convenient for searching and comparing the similarity of DNA seg-ments. After analyzing different formats of DNA graphic representations,a new graphic coding pattern for DNA sequence with binote and tristave method was suggested. The binote-tristave graphic code of DNA sequence is originated from the horizontal displacement of the digital coding plane of DNA nu-cleotides. It is one to one corresponding to the DNA letter coding, plotable and readable by computer. The binote-tristave DNA graphic code is especially suitable for searching and comparing the unknown DNA short sequences and is of significant value for the bioinformatic analysis of gene data.
出处
《生物物理学报》
CAS
CSCD
北大核心
2003年第2期167-170,共4页
Acta Biophysica Sinica
基金
国家自然科学基金项目(60171040)
