吸烟与肝癌关系的病例对照研究

Case control study for the relation of smoking and liver cancer

[目的 ]评估吸烟对肝癌发生、发展的影响 .[方法 ]在中国 2 4个城市和 74个农村地区 ,随机选择了 196 13名死于肝癌的吸烟者和 770 6名死于肝硬化的吸烟者进行回顾性调查研究 .[结果 ]吸烟可以导致肝癌的超额死亡 ,在 35岁以上的男性吸烟者中 ,肝癌的超额死亡率为 36 % ,吸烟者和非吸烟者导致肝癌的相对危险度为 1 36 ,95 %可信区间为 1 2 9～ 1 4 3,女性吸烟者和非吸烟者的相对危险度为1 2 7,95 %可信区间为 1 16～ 1 36 .每日吸烟量同肝癌的死亡也呈显著的正向关系 .[结论

OBJECTIVE To determine whether smoking is a co factor for the development of liver cancer.?METHODS?It was retrospectively analyzed from that the smoking habits of 19?613 cases died by liver cancer and 7?706 cases died by cirrhosis as control in 24 cities and 74 rural counties of China.?RESULTS?There was a 36% excess risk of death from liver cancer among smokers in the adult men over 35 year old and smoker versus non smoker RR was 1 36 with 95% of confidence interval 1 29～1 43. Smoker versus non smoker RR in woman was 1 27 with 95% of confidence interval 1 16～1 36.The RR was significantly related to daily cigarettes consumption.?CONCLUSION?Smoking can increase the risk of getting liver cancer.