摘要
应用第三代头孢菌素——头孢唑肟(ceftizoxime)对重症肺部感染的12例患者的治疗效果进行了临床观察,并对其中部分病例作了药物动力学监测,以探索第三代头孢菌素的用药剂量和用药途径。结果表明,静脉滴注给药,药物浓度高,维持时间长,治疗效果较好。头孢唑肟的用量,每日2g,分2次静脉滴注,于1h内滴完,对除绿脓杆菌以外的其他细菌感染,均已足够。
12 cases of severe pulmonary infection were treated with ceftizoxime, one of cepha-losporins of the third generation. Clinical observation and pharmacokinetics were carried out. The result showed that intravenous infusion was the best route of drug administration. It had the advantages of high serum concentration and prolonged maintenance of serum level. 1 gram of ceftizoxi-me, two times a day, was enough for most pathogens except Pseudomonas aeruginosa.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第1期10-12,共3页
Medical Journal of Chinese People's Liberation Army
关键词
肺炎
头孢唑肟
肺感染
Ceftizoxime
Pulmonary infection
Treatment