急性肺损伤血浆和肺淋巴液化学发光的改变

THE CHANGES IN CHEMILUMINESCENCE IN PLASMA AND LUNG LYMPH IN ENDOTOXIN-INDUCED LUNG INJURY

清醒绵羊内毒素急性肺损伤后,动脉血浆和肺淋巴液的诱发化学发光(ICL)显著增强,静脉血浆ICL增强不明显。提示,内毒素所致急性肺损伤时,肺内过氧化反应增强;脂质过氧化在急性肺损伤中起重要作用,血浆ICL是灵敏反映体内过氧化水平的生物物理化学指标。

The purpose of this study was to determine the role of lipid peroxidation by measuring the induced-chemiluminescence (ICL) of plasma and lung lymph in endotoxin-induced acute lung injury in awake sheep. The ICL of aortic plasma and lung lymph were significantly increased, but the ICL of venous plasma was not significantly increased after endotoxin infusion. The peak level of ICL was increased and its time was delayed after endotoxin. We conclude that lipid peroxidation plays an important role in endotoxin-induced acute lung injury, and ICL of arterial plasma is a sensitive marker in reflecting oxidant damage in lung.