摘要
用雷公藤对小鼠肾毒血清性肾炎进行治疗。结果表明,早期应用雷公藤可以明显抑制小鼠肾毒血清性肾炎脾淋巴细胞产生白介素-2的活性和血清抗肾抗体的水平,减轻尿蛋白的排泄,改善肾脏病理变化。本文进一步阐明了雷公藤免疫抑制作用的机制,为临床应用雷公藤提供了理论依据。
Interleukin 2 (IL-2) activity in spleen lymphocyte and anti-Rabbit IgG antibody from mice with nephrotoxic serum nephritis were examined to investigate immunosuppressive effect of Triterygium Wilfordii (TW), IL-2 bioactivity and serum anti-Rabbit IgG antibody were significantly higher in the group of nephrotoxic serum nephritis. The administration of TW prevented the overproduction of IL-2 and serum anti-Rabbit IgG antibody, and reduced excretion of urinary protein and renal histologic changes.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第2期90-92,共3页
Medical Journal of Chinese People's Liberation Army
关键词
雷公藤
肾炎
白细胞介素2
Triterygium Wiifordii
Interleukin 2
Nephrotoxic serum nephritis
