外周血造血干细胞动员剂硫酸葡聚糖临床应用初步观察

PRELIMINARY REPORT OF CLINICAL USE OF DEXTRAN SULFATE: A MOBILIZER OF HEMATOPOIETIC STEM CELLS FROM PERIPHERAL BLOOD

应用硫酸葡聚糖作外周血干细胞动员剂,对3例急性白血病病人静脉注射,于注药后1 1/2 h开始采集外周血干细胞,注药后3h外周血干细胞数量较注药前增加3～8倍,分离次数由注药前的6次减少到1～2次,3例患者2例分离2次,1例分离1次。硫酸葡聚糖对肝、肾功能亦无明显损害,凝血系统功能检查也无明显异常。

The use of dextran sulfate(DS) as a mobilizer for hematopoietic stem cells in three acute leukemia patients was reported. The total dosages used were 2070mg, 1950mg and 1020mg respectively. One and half hours after infusion, nucleated and mononucleate cells in peripheral blood were collected in amounts of 20.41×109,25.58×109 and 24.058×109, respectively. They were used as autologous transplantation with success. After infusion, the frequency of separation procedures was reduced from 9 times to 1-2 times. KPTT, TT and PT values returned to the pre-infusion levels in 24 hours, and the hepatic and renal functions did not show any evident change. Therefore, DS appears to be a safe and effective mobilizer for the hematopoietic stem cells.