正常人群红细胞胆固醇与血浆脂蛋白组分胆固醇水平关系的研究

A STUDY ON THE CORRELATION BETWEEN ERYTHROCYTE CHOLESTEROL AND DIFFERENT LIPOPROTEIN CHOLESTEROL LEVELS IN SERUM IN HEALTHY SUBJECTS

本文报告了1～90岁2333名正常人群红细胞胆固醇(REC—C)、高密度脂蛋白胆固醇(HDL—C)及亚组(HDL_2—C、HDL_3—C)、低密度脂蛋白胆固醇(LDL—C)、极低密度脂蛋白胆固醇(VLDL—C)水平及相关关系。结果显示RBC—C水平随年龄增长而升高,并呈正相关(r=0.154,P<0.05)。男、女RBC—C与HDL—C呈正相关,RBC—C与HDL_2—C、HDL_3-C、LDL—C、VLDL—C呈负相关。男性RBC-C与LDL—C相关密切(偏相关系数R=0.157,P<0.05),女性RBC—C与VLDL—C相关密切(偏相关系数R=0.153,P<0.05)。RBC—C与HDL-C、HDL_2—C、HDL_3-C、LDL-C、VLDL-C相关方向、相关强度因年龄增加,性别不同而变化。结合有关资料讨论了RBC—C水平变化及RBC—C与血浆脂蛋白组分胆固醇相关关系在动脉硬化形成及预防中的意义。

This paper reported tlie levels and correlative relations of erythrocyte cholesterol (RBC-C), and serum HDL-C, HDL2-C, HDL3-C, LDL-C and VLDL-C in sub-group among 2333 normal individuals aged 1-90. The rese- arch showed that RBC-C level decame higher as age increassed and showed positive correlation (Correlation coefficient: r=0.154, P<0.05), The relat- ionship between RBC-C and HDL-C, in both males and females, showed positive correlation and that between RBC-C and HDL2-C, HDL3-C LDL-C and VLDL-C showed negative correlation. RBC-C of males was closely co- rrelated to LDL-C (partial correlation coefficient: R=0.157, P<0.05), and that of females closely correlated to VLDL-C(Partial correlation coefficient: R=0.153, P<0.05), The correlative direction and correlative intensity of RBC-C and HDL-C, HDL2C, HDL3-C, LDL-C, VLDL-C varied obviously with increasing age and sexual difference, This paper discussed the changes of RBC-C level and the significance of the relations between RBC-C and different serum lipoprotein cholesterol levels in the process of arterioscler- osis formation and prevention.