摘要
通过母鼠,胎盘和胎鼠血汞浓度测定和胎盘病理学检查,进一步研究无机汞的胎盘转运功能。将妊娠大鼠随机分为四组,皮下注射蒸溜水和HgCl_2溶液,剂量为0.6、0.3、0.15mg/kg。结果表明,HgCl_2各剂量组的母鼠、胎盘和胎鼠血汞浓度呈现明显的剂量—反应关系,两者比较有显著正相关。胎盘病理改变表现滋养层和血窦部组织被玻坏,证明氯化汞能经胎盘转运。
To clarify the maternal-fetal transfer of inorganic mercury across the
placenta, concentrations of mercury of maternal blood, placental blood and
fetal blood in rat as well as pathological changes of placental tissue were
determined. The pregnant rats were divided into 4 experimental groups
randomly. Mercuric chloride (0.15, 0.30, 0.60mg/kg) and distilled water were
injected into the pregnant rats daily within 7th～16th days. The results
showed that there was positive correlation between the concentrations of
mercuric chloride in maternal and placental (or. maternal and fetal, place-
ntal and fetal) blood. A clear dose-effect relationship was indicated. The
pathological changes showed that the structure df trophoblast and blood sinus
were destructed. It may be concluded that mercuric chloride can be transfe-
red through the transplacental route.s
出处
《解放军预防医学杂志》
CAS
北大核心
1992年第4期266-268,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
氯化汞
血汞浓度
胎盘转运
mercuric chloride
blood mercury concentration
placental transfer
placental pathology
