摘要
目的 :观察消痔栓的急性毒性 ,测定其半数致死量。方法 :简化机率法。结果 :测得消痔栓灌胃给药的半数致死量 (LD50 )为 1 1 37 2 2mg/kg。LD50 可信限为 870 96~ 1 4 79 1 1mg/kg。平均可信限率为 2 6 74 %。结论 :消痔栓的半数致死量为有效量的 8倍 。
Objective:To investigate the acute toxicity of suppository archosyrinx,and calculate the value of LD 50 .Methods:The test of simplified rate.Results:The LD 50 value of suppository archosyrinx is 1137 22mg/kg.The confidence limit is 870 96~1479 11mg/kg.The everage rate of confidence limit is 26 74%.Conculusion:The LD 50 of suppository archosyrinx is 8 times more than normal dosage,so it is rather safe in clinical therapy. [
出处
《湖北省卫生职工医学院学报》
2003年第2期6-7,共2页
Journal of Hubei Medical Staff College