Xlk的主要药效学及其在小鼠体内时间的药理学研究

Study of xlk on anaglesic effect and the chronopharmacology in mice

目的 研究 xlk的主要药效学及其对小鼠的急性毒性、药效学的昼夜节律性。方法 用热板法、扭体法了解 xlk的镇痛作用强度及小鼠在 0 8:0 0、1 2 :0 0、1 6:0 0、2 0 :0 0、2 4 :0 0灌胃 xlk后 ,观察其急性死亡率 ,对热板刺激的反应的变化。结果 xlk对小鼠的急性毒性有明显的昼夜节律 ,毒性作用的峰值在暗中期 ;xlk的镇痛作用明确且存在昼夜节律性差异 ,作用峰值在天明前期。结论 xlk有良好的镇痛作用 。

Objective To study the main pharmacodynamics, acute toxicity and circadian rhythm of xlk in mice. Methods Hot plate procedure and irritation by acetic acid were employed to study analgesic effect. The subjects were observed for the changes of acute toxicity and analgesic effect at the baseline time 08:00,12:00,16:00,20:00,24:00 after xlk was administered.Result Obvious circadian rhythm was observed for acute toxicity and anlgesic effect of xlk. The acrometron of xlk's acute toxicity was in the middle of dark period; The acrometron of anlagesic effect of xlk was in the forward of light period. Conclusion Xlk has obvious analgesic effect and acute toxicity which show daily rhythmic vriation in mice.