疯牛病感染因子的检测

The Detection of Bovine Spongiform Encephalopathy Agent for Bio-products Made from Cow Blood

研究目的是对北京某公司研制的一种牛血源性生物制品进行疯牛病感染因子的检测。通过对供体牛及其产地牛进行疯牛病流行病学调查及免疫细胞化学、Westernblot和组织病理学检测,确认这些供体牛没有感染疯牛病,以其血液作为原料研制的生物制品没有携带疯牛病病原的危险,本研究也为在我国进一步建立牛源性药品、生物制品中疯牛病感染因子的检测和评估提供了科学资料。

The research project was made to confirm whether or nor the bioproducts,which was made from cow blood and produced by a company in Beijing,were contaminated with bovine spongiform encephalopathy(BSE)agent.By the investigation of epidemiology of BSE and the detection with immunocytochemistry,Western blot and histopathology for 51 brains from the donor cattle and the cattle which were in the place where the donor cattle came from,we could confirm that the cattle tested were not infected with BSE and that it was impossible for the bioproducts made from their blood to bear the agent of BSE.This report also provided information for the detection and evaluation of BSE on medicine and bioproducts derived from cow in China.