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醒神药物莫达非尼合成方法的改进 被引量：2

A New Route to Stimulant Drug Modafinil
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摘要 本文以 1条简单有效的新路线合成了莫达非尼 ,总收率为 6 1.6 %。首先在 Fe(NO3 ) 3 ·9H2 O催化下以二苯甲醇和巯基乙酸合成二苯甲基巯基乙酸 ,进而进行酰胺化反应 ,生成相应的酰胺化合物在双氧水作用下将硫醚氧化为亚枫得到目标化合物。产物用 IR,NMR确证其结构。 A convenient and efficient procedure was developed for the synthesis of Modafinil. This method involved the condensation of diphenylmethyl alcohol with thioglycolic acid in the presence of Fe(NO 3) 3·9H2O amidation of carboxy group and the oxidation of thio-ether bond. The compound was confirmed by IR, 1HNMR and 13C-NMR.
作者 方玉春 褚世栋
机构地区 中国海洋大学海洋药物与食品研究所
出处 《青岛海洋大学学报（自然科学版）》 CSCD 北大核心 2003年第4期537-539,共3页 Journal of Ocean University of Qingdao
关键词 醒神药物 莫达非尼 合成 催化 2-(二苯甲基亚磺酰基)乙酰胺 中枢兴奋药 modafinil synthesis Fe(NO3) 3.9H 2O catalysis
分类号 R971.7 [医药卫生—药品] TQ460.31 [化学工程—制药化工]
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参考文献10

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同被引文献28

  • 1王淑惠,葛盛秋.民用航空医学进展──美国航空航天医学会第65届年会论文简介[J].中华航空医学杂志,1994,5(4X):242-245. 被引量：2
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青岛海洋大学学报（自然科学版）
2003年 第4期

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