药物对进驻高原青年睡眠剥夺及力竭运动时肺通气功能的影响

Effects of rhodiola and acetazolamide on pulmonary ventilation function after sleep deprivation and exhaustive exercise at high altitude

目的 :探讨红景天与乙酰唑胺对进驻高原青年睡眠剥夺及力竭运动时肺通气量的影响。方法 :将进驻海拔 370 0m 1个月的 2 4名健康青年随机分为 3组 ,每组 8人。受试者用EGM型踏车功量机做坐位踏车运动。初始负荷功率 2 5W ,每 3min递增 2 5W ,直至力竭。计算每位受试者的每分通气量 (VE)。第二次实验为 2 4h睡眠剥夺后 ;第三次实验为 3组受试者分别口服红景天、乙酰唑胺和安慰剂 2 0d后 ;第四次实验为服药后 2 4h睡眠剥夺后 ,实验方法与第一次相同。结果 :红景天组和乙酰唑胺组服药后与服药后睡眠剥夺后VE较服药前、睡眠剥夺后及对照组明显降低 ,差异非常显著 (P <0 .0 1 )。结论

Objective: To study the effects of rhodiola and acetazolamide on pulmonary ventilation function of young soldiers after sleep deprivation and exhaustive exercise at 3 700 m altitude. Methods:Twenty four young men living at 3 700 m altitude for 1 month were randomly divided into rhodiola group, acetazolamide group and control group, and constantly pedaled the EGM efficiency-bicycle (initial load 25 W, increase progressively 25 W per 3 min) to exhaustion. The ventilation volume per minute(VEBTPS) was calculated after depriving sleep for 24 hours and after taking medicine for 20 days. Results: Compared with control group, VEBTPS decreased significantly after taking rhodiola and acetazolamide for 20 days or after depriving sleep for 24 hours ( P <0.01).Conclusion: Both rhodiola and acetazolamide could improve the pulmonary ventilation and work efficiency at high altitude.