单纯性肥胖-儿童肾素血管紧张素系统与心肌肥厚的关系

Effects of renin-angiotensin system on myocardial hypertrophy in simple obesity children

目的 探讨单纯性肥胖儿童肾素 血管紧张素系统与心肌肥厚的关系。方法 分别对 31例单纯性肥胖儿童和 31例正常对照组儿童测量其体质指数 (BMI)、左室心肌质量 (LVM )、血浆血管紧张素Ⅱ (AngⅡ )、及醛固酮 (ALD)浓度。结果 1.肥胖组AngⅡ、ALD均显著高于对照组 ;2 .肥胖组LVM显著高于对照组 ;3.肥胖组中AngⅡ及ALD均与LVM之间存在直线正相关和回归关系。 结论 肥胖组儿童存在肾素 血管紧张素 醛固酮系统 (RAAS)异常激活 。

Objective To discuss the effects of rennin-angiotensin system on myocardial hypertrophy in simple obesity children.Methods We randomly selected 31 simple obesity children and 31 normal children. Body mass index(BMI),left ventricular mass(LVM) and level of serum angiotensinⅡ (AngⅡ), aldosterone (ALD) were measured.Results 1. Compared to controls, the AngⅡ and ALD levels of serum increased significantly in obesity children;2. BMI, LVM increased significantly in obesity children;3. In obesity children, the levels of AngⅡ and ALD both have linear corre1ation with LVM.Conclusion The abnormal activated renin-angiotensin-aldosterone system have effects on myocardial hypertrophy in simple obesity children.