主要热应激蛋白和p53在鼻咽癌中的表达

Expression of main heat stress proteins and p53 in nasopharyngeal carcinoma

目的 :探讨鼻咽癌 (NPC)组织中主要热应激蛋白 (HSPs)和 p5 3表达水平及其临床意义。 方法 :用Westernblot方法检测 38例NPC组织和 17例鼻咽慢性炎症组织中HSPs和 p5 3的表达。 结果 :HSP 2 7和 p5 3在NPC组织中表达升高 ,与鼻咽炎症组织比较 ,差异有显著性意义 (P <0 .0 5 ) ;但在NPC的组织分型和临床分期之间 ,差异无显著性意义 (P >0 .0 5 )。HSP 90和HSP 70在NPC组织和慢性炎症组织间差异无显著性意义 (P>0 .0 5 )。结论 :HSPs和 p5 3在NPC组织中存在一定程度的异常表达 。

Objective:To investigate the expression and the significance of main heat stress proteins (HSPs) and p53 in nasopharyngeal carcinoma.Method:Tissues homogenate and western blot were used to determine the level of HSPs and p53.Result:HSP27 and p53 elevated remarkably (P< 0.05 ) while HSP90 and HSP70 showed no significance between nasopharyngeal carcinoma and control tissues. Elevated level of HSP27 and p53 don't correlated with histological type and clinical stage.Conclusion:Expression of HSPs and p53 show some difference in nasopharyngeal carcinoma tissue. These data suggest that HSPs and p53 may play a role in the development of nasopharyngeal carcinoma.