高渗盐溶液对海水浸泡失血性休克大鼠动脉血气和活存率的影响

EFFECTS OF HYPERTONIC NaCl/NaAc ON BLOOD GAS AND ACID-BASE STATUS OF HEMORRHAGE-SHOCKED RATS IMMERSED IN SEAWATER

目的 :探讨小剂量高渗氯化钠 (HS)和复方高渗醋酸钠 (HSA)复苏对海水浸泡失血性休克大鼠的治疗效果。方法 :应用海水浸泡失血性休克大鼠模型 ,以生理盐水 (NS)为对照组 ,观察小剂量HS和HSA对其动脉血气的影响。结果 :NS组 30min后动脉血 pH降低、BE -B、HCO3 显著降低 ,PCO2 显著升高 ,而HS组和HSA组动脉血pH升高 ,BE -B、HCO3 、血压比对照组好 ,PCO2 也低於NS组 ,存活时间延长 ,血浆Cl-浓度HSA组低于HS组 (P <0 .0 5 )。结论 :HS和HSA对失血性休克早期复苏效果较好 ,HSA能更有效地升压、稳压、稳定酸碱平衡、减轻高氯酸血症、纠正酸中毒。

Objective:To investigate the effect of small votame hypertonic solution on hemorrhage shocked rats immersed in seawater.Methods:Rats were chloride sodium injection(NS); hypertoic chloride sodium(HS);and hypertonic acetate(HSA). Results: The results indicated :NS can further decrease the pH, Pco2, BE-B, Hco3, Blood pressure, respiratory and increase acidosis of hemorrhagic shock rats immersed in seawater. HS and HSA almost didn't decrease but can increase the pH, Pco2, BE-B, Hco3, blood pressure,respiratory and survival rates. Serum Cl - level was significantly different between HS and HSA groups( P <0.05).Conclusions: The effect of HS and HAS for early treatment of hemorrhagic shock immersed in seawater is better. HSA can significantly increase blood pressure, maintain smoothly, treat the acidosis and change blood gas acid-base status.