莫达芬尼对48h睡眠剥夺时视听运动反应和疲劳感的影响

Effects of Modafinil on Visual and Auditory Reaction Abilities and Subjective Fatigue Level during 48 h Sleep Deprivation

目的观察 48h睡眠剥夺 (sleepdeprivation ,SD)条件下正常人服用新型促醒剂莫达芬尼改善视听反应能力和疲劳感的效果。方法 6名健康男性青年志愿者 ,在 2次SD实验 (间隔 2周 )中交叉服用莫达芬尼和安慰剂 ,SD时间从第 1天 7∶0 0至第 3天 7∶0 0 ,于第 2天 0∶0 0、1 6∶0 0和第 3天 0∶0 0分别服用莫达芬尼 2 0 0mg或安慰剂 ,采用随机双盲给药 ,并在第 1天 2 1∶0 0及每次服药后 1h、3h、5h、7h各完成 1次测试 ,内容包括 :1 )声、光刺激运动反应时 ;2 )注意分配 ;3)临界闪光融合频率 (criticalflickerfusionfre quency ,CFF) ;4) .斯坦福嗜睡量表 (stanfordsleepinessscale ,SSS) ;5 )自认疲劳分级表 (ratingofper ceivedexertion ,RPE)。结果与安慰剂组比较 ,第 2、3次服用莫达芬尼后CFF值较安慰剂组明显升高 ,斯坦福量嗜睡表、RPE表分值较安慰剂组明显下降 ;声、光刺激运动反应时与注意分配无明显变化。

Objective To investigate the effects of modafinil, a new central stimulant, on visual and auditory motion reaction ability and subjective fatigue level during 48 h sleep deprivation(SD). Method Six male healthy young volunteers were exposed to two 48 h periods of continuous wakefulness during the crossover experiment. In one period, three 200 mg doses of modafinil were given and in the other, separated by two weeks, matching placebos were administered. The SD time started from 7∶00 of the first day to 7∶00 of the third day. Drugs were given at 0∶00,16∶00 of the second day and 0:00 of the third day. Variables, including visual and auditory motion reaction time, attention distribution, critical flicker fusion frequency(CFF), Stanford sleepiness scale(SSS) and rating of perceived exertion(RPE), were tested at 21∶00 of the first day and 1,3,5,7 h after each drug administration. Result After 2～3 does of modafinil ,the CFF level was obviously enhanced while the scores of Stanford sleepiness scale and RPE were markedly reduced. The visual and auditory motion reaction ability, as well as the attention distribution, showed no significant change. Conclusion Modafinil can effectively reduced the subjective fatigue and sleepiness levels during SD.