期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

定量^(99m)Tc-MIBI肺部断层显像评估非小细胞肺癌放射治疗敏感性的应用研究 被引量：4

Quantitative evaluation of radiotherapeutic response in non-small cell lung cancer patients by tech netium-99m MIBI SPECT
下载PDF
导出
摘要 目的:应用99mTc-甲氧基异丁基异腈(MIBI)肺部断层显像方法对非小细胞肺癌肿块的放射治疗敏感性进行定量分析。材料与方法:对39例非小细胞肺癌患者进行99mTc-MIBI肺部断层显像,分析敏感组与不敏感组早期比率(ER),延迟比率(DR)和滞留指数(RI)之间的区别。结果:敏感组的DR、RI值明显高于不敏感组。结论:肺部99mTc-MIBI断层显像通过DR和RI两种参数选定,可对非小细胞肺癌的放疗敏感性进行评估。 Objective:Using technetium-99m MIBI SPECT to quantitatively evaluate the radiotherapeutic response in non-small cell lung cancer patients.Methods:MIBI lung imaging was used in39non-small cell lung cancer patients,to analyze the differences of early ratio(ER),delayed ratio (DR)and retention index (RI )in the responder group and the non-responder group.Results:The DR,RI in responder group were significantly higher than that in non-responder group.Conclusion:By measuring DR and RI,99m Tc-MIBI lung SPECT imaging can be used as a method of evaluation of radiotherapeutic response in non-small cell lung cancer.
作者 宁本军 王志春 王发升 罗萍 张伟 金刚 芮东红 陆炎
机构地区 哈尔滨医科大学第二临床学院核医学科 首都医科大学附属宣武医院放射线科
出处 《中国临床医学影像杂志》 CAS 2003年第4期255-257,共3页 Journal of China Clinic Medical Imaging
关键词 肺肿瘤 放射性核素显像 lung neoplasms radionuclide imaging
分类号 R734.2 [医药卫生—肿瘤] R817.4 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献12

  • 1Mote PA, Davey MW, Davey RA, et al. Paclitaxel sensitizes mtdtidrug resistant cells to radiation. Anticancer Drugs, 1996, 7(2): 182-188.
  • 2Rasey JS, Koh WJ, Grierson JR, et al. Radiolabelled fluoromisonidazole as an imaging agent for tumor hypoxia, lnt J Radiat Oncol Biol Phys, 1989, 17 (5): 985-991.
  • 3Cook GJ, Houston S, Barrington SF, et al. Technetium-99m-labeled HL91 to identify tumor hypoxia: correlation with fluorine-18-FDG. J Nucl Med, 1998, 39 (1): 99-103.
  • 4Pauwels O, Gozy M, Van Houtte P, et al. Cross resistance and collateral sensitivity between cytotoxic drugs and radiation in two human bladder cell lines. Radiother Oncol, 1996, 39 (1):81-86.
  • 5Hill BT, Deuchars K, Hosking LK, et al. Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated X irradiation in vitro. J Nail Cancer lnst, 1990, 82 (7): 607-612.
  • 6McClean S, Hosking LK, Hill BT. Expression of P-glycoprotein-mediated drug resistance in CHO cells surviving a single X-ray dose of 30Gy. Int J Radiat Biol, 1993, 63 (6): 765-773.
  • 7Piwnica-Worms D, Chiw ML, Budding M, et al. Functional imaging of mttltidrug resistance P-glycoprotein with an organotechnetium complex. Cancer Res, 1993, 53: 972-984.
  • 8Higashi I, Wakao H, Nakamura K, et al. Quantitative gallium-67 scanning for predictive value in primary lung carcinoma.J Nucl Med, 1980, 21 (7): 628-632.
  • 9Yarnaji S. Usefulness of ^201T1 SPECT in the evaluation of treatment effect for primary lung cancer. Kaku Igaku, 1995, 32(12): 1333-1340.
  • 10Ichiya Y, Kuwabara Y, Sasaki M, et al. A climcal evaluation of FDG-PET to assess the response in radiation therapy for bronchogenic carcinoma. Ann Nucl Med, 1996, 10 (2): 193-200.

同被引文献25

  • 1李玲,于金明,邢力刚,朱慧,李国梁,方永存.^(99m)Tc-HL91 SPECT肺癌乏氧显像与放疗疗效关系的初步研究[J].中华放射肿瘤学杂志,2006,15(1):31-34. 被引量：14
  • 2[1]Munley MT,Marks LB,Scarfone C,et al.Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer:Challenges and prospects.Lung Cancer,1999,23 (2):105
  • 3[2]Balogh JB,Caldwell CB,Ung YC,et al.Interobserver variation in contouring gross tumour volume in carcinoma of the lung associated with pneumonitis and atelectasis the impact of 18 FDG-hybrid pet fusion.Int J Radiat Oncol Biol Phys,2000,48 (3 Suppl Ⅰ):128
  • 4[3]Bradley J,Thorstad WL,Mutic S,et al.Impact of FDG PET on radiation therapy volume Delineation in non-small-cell lung cancer.Int J Radiat Oncol Biol Phys,2004,59:78
  • 5[4]van Der Wel A,Nijsten S,Hochstenbag M,et al.Increased therapeutic ratio by 18FDG-PET CT planning in patients with clinical CT stage N2～3 M0 non-small-cell lung cancer:A modeling study.Int J Radiat Oncol Biol Phys,2005,61 (3):649
  • 6[5]Ashamalla H,Rafla S,Parikh K,et al.The contribution of integrated PET/CT to the evolving definition of treatment volumes in radiation treatment planning in lung cancer.Int J Radiat Oncol Biol Phys,2005,63 (4):1016
  • 7[6]Fox JL,Rengan R,O'Meara W,et al.Does registration of PET and planning CT images decrease interobserver and intraobserver variation in delineating tumor volumes for nonsmall-cell lung cancer? Int J Radiat Oncol Biol Phys,2005,62 (1):70
  • 8[7]Vesselle H,Grierson J,Muzi M,et al.In vivo validation of 3'deoxy-3'-[18F] fluorothymidine ([18F] FLT) as a proliferation imaging tracer in humans:Correlation of[18 F] FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors.Clin Cancer Res,2002,8 (11):3315
  • 9[8]Eschmann SM,Paulsen F,Reimold M,et al.Prognostic impact of hypoxia imaging with 18 F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy.J Nucl Med,2005,46 (2):253
  • 10[10]Furuta M,Nozaki M,Kawashima M,et al.99mTc-MIBI scintigraphy for early detection of locally recurrent non-small cell lung cancer treated with definitive radiation therapy.Eur J Nucl Med Mol Imaging,2003,30 (7):982

引证文献4

二级引证文献5

中国临床医学影像杂志
2003年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部