急性脑卒中后抑郁的临床观察

Clinical observation of treatment effect on depression after stroke

目的观察急性脑卒中后抑郁与病损部位、神经功能缺损程度的关系 ,以及百忧解治疗此症的疗效。方法对 86例急性脑卒中患者进行Zung氏抑郁自评量表 (self ratingdepressionscale,SDS)检测 ,SDS≥ 50分为急性脑卒中后抑郁 ,观察抑郁症状与病损部位、神经功能缺损程度的关系 ,对有抑郁症状的患者给予百忧解治疗。结果符合入选条件的有 34例 (其中轻度 2 7例、中度、重度 7例 ) ,抑郁症状与疾病严重程度呈正相关 (P <0 .0 5) ,且皮质下卒中患者抑郁的发生率高于大脑皮质及小脑卒中患者 (P<0 .0 1 ) ;氟西汀 (百忧解 )治疗有效。结论急性脑卒中后抑郁与疾病严重程度呈正相关 。

ObjectiveTo analyze th e relationship of depression after stroke with the location of lesion and the leve l of central nervous system (CNS) damage, and evaluate the treatment effect.Methods86 stroke patients were evaluated by Zung's self-rating depression scale (SDS). If SDS score ≥50 points, the patient was s elected as subjects for this study and treated with fluoxetine. The relationship of depression with the location of lesion and the level of CNS damage, and the treatment effect were analyzed.ResultsThere were 3 4 cases evaluated as depression (with 27 light depressive cases, 7 moderate depr essive and severe depressive cases). The symptom of depression has a positive co rrelation to the damage level ( P<0.05). The depression inci dence of patients with acute sub-cortex stroke is higher than that of cerebral cortex and cerebellum stroke ( P<0.01). Fluoxetine has a goo d effect on depression after stroke.Conclusions Th e symptom of depression after stroke has a positive correlation to the damage le vel. Fluoxetine has a good effect on depression after stroke.