中药地菍黄酮类成分的分离与鉴定

Studies on the flavonoids constituents of Chinese herb Melastoma dodecandrum

目的 对地 (MelastomadodecandrumLour)全草的化学成分进行分离鉴定。方法 溶剂萃取及各种色谱技术分离纯化 ,经UV ,IR ,1H NMR ,13C NMR ,MS以及化学方法鉴定了它们的结构。结果 分离得到 7个化合物 ,分别是木犀草素(Ⅰ )、木犀草素 7 O β 葡萄糖苷 (Ⅱ )、木犀草素 7 O β 半乳糖苷 (Ⅲ )、槲皮素 (Ⅳ )、槲皮素 3 O β 葡萄糖苷 (Ⅴ )、槲皮素 3 O β 半乳糖苷 (Ⅵ )、广寄生苷 (Ⅶ )。

OBJECTIVE To separate and identify the chemical constituents of the whole plant of chinese herb Melastoma Dodecandrum Lour.METHODS The flavonoid constituents were isolated by solvent extraction and chromatography.Their chemical structures were identified on the basis of physic-chemical constant and spectral data.RESULTS Seven compounds were isolated and identified as luteolin (Ⅰ),luteolin-7-O-β-glucoside (Ⅱ),luteolin-7-O-β-galactoside (Ⅲ),quercetin (Ⅳ),quercetin-3-O-β-glucoside (Ⅴ),quercetin-3-O-β-galactoside (Ⅵ) and avicularin (Ⅶ).CONCLUSION The above-mentioned compounds were separated from the plant for the first time.