大剂量谷维素和维生素B_1治疗功能性消化不良

High dosage Oryzanol and Vitamin B_1 in the treatment of functional dyspepsia

目的 探讨大剂量谷维素和维生素 B1对功能性消化不良 ( FD)及患者情绪障碍的疗效。方法 选取符合“罗马标准”确诊为 FD,同时伴有明显的抑郁及焦虑情绪的患者 86例随机分为治疗组和对照组 ,对照组根据治疗个体化原则选用吗丁啉、雷尼替丁、硫糖铝或铝碳酸镁等常规治疗。治疗组除上述常规治疗外 ,还予以心理疏导及大剂量谷维素和维生素 B1各 1 0 0 mg,3次 /d,8周为 1个疗程。根据症状积分变化评定疗效。结果 治疗组治疗 8周后的显效率和总有效率分别为 65 .1 %和 86.0 % ,而对照组则为 5 1 .1 %和67.4%。经统计学处理 ,两组的显效率差异无显著性 ( P >0 .0 5 ) ,而总有效率差异有显著性 ( P <0 .0 5 )。结论 大剂量谷维素和维生素 B1联合心理及常规药物治疗伴有抑郁和焦虑情绪的 FD患者 ,能够促进临床症状缓解 ,精神状态的改观 ,而且不因加大用药量而出现其它副反应。

Objective To observe the clinical effect of high dosage Oryzanol and Vitamin B 1 on functional dyspepsia.Methods 86 patients accompany with disturbance in emotion were divided into treatment group and control group,the control group patients were individualization treatment with Mutinline、Ranitidine、Sucralfate、Hydrosulfites et al, the treatment group patients were given Oryzanol 100mg Tid and Vitamin B 1 100mg Tid for 8 weeks, except the individualization treatment. The final diagnosis of functional dyspepsia was based in “Rome standard”.Results In the treatment group the significant rate was 65.1% and the total utility rate was 51.1% while in control group the rates were 86.0% and 67.4%,respectively.No difference of the significant utility rate between the treatment group and control group(P>0.05).But the total utility rates were the significant difference between the two groups(P<0.05).Conclusions High dosage of Oryzanol and Vitamin B 1 can get good clinical effect in the treatment of functional dyspepsia.