1Lien E,Sellati TJ, Yoshimura A, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem, 1999,274 : 33419-33425.
2Medzhitov R, Prestom-Hurburt P, Janeway CA. A human homologue of the Drosophile Toll protein signals activation of adaptive immunity. Nature, 1997,388: 394-397.
3Muzio M, Mantovani A. Toll-like receptors. Microbes Infect, 2000,2:251-255.
4Yang RB, Mark MR, Gray A, et al. Toll-like receptor 2-mediates lipopolysaecharide-indueed cellular signaling. Nature, 1998, 395 :284-288.
5Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science,1999,285 : 736-739.
6Takeuchi O, Hoshino K,Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity, 1999,11:443-451.
7Ozinsky A, UnderhiU DM, Fontenot JS, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Nail Acad Sci USA,2000,97:13766-13771.
8Gordon S. Pattem recognition receptors:doubling up for the innate immune response. Cell,2002,111:927-930.
9Asea A,Rehli M,Kabingu E, et al. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor(TLR) 2 and TLR4. J Biol Chem, 2002,277 : 15028-15034.
10Thoma-Uszynski S,Stenger S, Takeuchi O,et al. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science, 2001,291 : 1544-1547.
5Yang YH,Chuang YH,Wang LC,et al.The immunobiology of Henoch-Schonlein purpura.Autoimmun Rev,2008,7:179-184.
6Arira S,Uematsu S,Takeuchi O.Pathogen recognition and innate immunity.Cell,2006,124:783-806.
7Li M,Zhou Y,Feng G,et al.The critical role of Toll-like receptor signaling patlways in the induction and progression of autoimmune disease.Curr Mol Med,2009,9:356-374.
8Marshak-Rothestein A.Toll-like receptor in systemic autoimmune disease.Nature Rev Immunol,2006,6:823-835.
9Akira S.Pathogen recognition by innate immunity and its singnaling.Proc Jpn Acad Ser B Phys Biol Sci,2009,85:143-155.
10Baccala R,Hoebe K,Kono DH,et al.TLR-dependent and TLRindependent pathways of type Ⅰ interferon induction in systemic autoimmunity.Nat Med,2007,13:543-551.