肺原性心脏病患者血浆脑钠素含量测定

Determination of plasma brain natriuretic peptide in patients with chronic cor pulmonale

目的 :测定慢性原肺原性心脏病 (肺心病 )患者血浆脑钠素 (BNP)含量。方法 :2 5例肺心病患者分别于急性加重期和缓解期测定血浆BNP水平 ,与 30例正常对照进行比较 ,并分析其与 paO2及右室射血前期时间(RVPEP) /肺动脉血流加速时间 (AT)的相关性。结果 :肺心病急性加重期血浆BPN水平 (2 2 1.95± 4 3.2 2 )ng/L高于缓解期水平 (5 3.86± 12 .83)ng/L ,且 2者均高于正常对照组的 (11.98± 2 .18)ng/L(P <0 .0 0 1) ,2者均与 paO2呈负相关 (r分别为 - 0 .77,- 0 .5 9,P均 <0 .0 1) ,与RVPEP/AT呈正相关 (r分别为 0 .76 ,0 .5 7,P均 <0 .0 1)。结论 :血浆BNP可延缓肺动脉压力的进一步升高 ,提高血浆BNP水平有可能用来治疗肺心病。

Aim:To study the plasma level of brain natriuretic peptide (BNP)and its pathophysiological significance in patients with chronic cor pulmonale.Methods: The plasma BNP levels in 25 cases of chronic cor pulmonale were measured,and the relationship between it and p a O 2, RVPEP/AT were analyzed.Results:The levels of BNP at acute stage(221.95±43.22) ng/L and stable stages(53.86±12.83) ng/L for chronic cor pulmale group were both higher than that in the normal control group(11.98±2.18) ng/L( P <0.001), and were negatively correlated with p a O 2( P <0.01),positively correlated with RVPEP/AT( P <0.01).Conclusion: It is suggested that the higher level of BNP could prolong the further elevation of pulmonary artery pressure,and raising the plasma levels of BNP maybe a new method to treat cor pulmonale.