期刊文献+

新型导电高聚物对神经元修补元件的表面改性 被引量:1

Surface Modification of Neural Prosthetic Devices with a Novel Conducting Polymer
下载PDF
导出
摘要 利用一种新型的导电聚合物——聚3,4-二氧化乙烷噻吩(PEDOT)的衍生物PEDTM,成功地在用微加工技术制作的神经元修补元件的电极上制得了导电涂层。该导电聚合物既克服了聚吡咯由于α—β(β?键接而产生的缺陷, 又克服了EDOT在水中溶解度小,无法在生物分子的掺杂下电化学合成PEDOT/生物分子导电涂层的缺陷。SEM和AFM照片表明PEDTM/PSS导电涂层具有粗糙的表面形貌,表面积增加,其阻抗也比未涂层前降低很多,在1 kHz处其阻抗值降低了两个数量级。研究结果表明,PEDTM/生物分子导电涂层的阻抗比聚吡咯/生物分子涂层降低得更多。 PEDTM, a derivative of poly3, 4-ethylenedioxythiophene, was found a novel conducting polymer. PEDTM was electrochemically deposited onto the surface of micromachined neural prosthetic device. PEDTM has neither the undesiredα—coupling that is often found in polypyrrole, nor the aqueous solubility as low as that of EDOT. Thus, the film of PEDTM/biomolecules was successfully obtained. SEM and AFM images indicated that the coatings had rough surface morphology. It provided an intimate contact with neural cells. Impedance spectroscope indicated that the impedance of the conducting polymer coating was lower than that of the bare gold electrodes.
出处 《电子元件与材料》 CAS CSCD 北大核心 2003年第8期18-19,22,共3页 Electronic Components And Materials
关键词 导电聚合物 神经元修补元件 表面改性 conducting polymer neural prosthetic devices surface modification
  • 相关文献

参考文献7

  • 1Brown WJ, Babb T L, Soper H V, et al. Tissue reactions to long-term electrical stimulation of the cerebellum in monkeys[J]. J Neueosurg. 1977,47: 366-379.
  • 2Thomas C A, Zong K, Schottland P, et al. Poly(3,4-alkylenedioxypyrrole)s as highly stable aqueous-compatible conducting polymers with biomedical[J]. Adv Mater, 2000,(3): 222.
  • 3Gaupp C L, Zong K, Schottland P, et al. Organic electrochemistry of a highly stable electrochromic polymer[J]. Macromolecules, 2000,33:1132.
  • 4Heywang G, Jonas F. Poly(alkylenedioxythiophene)s-new, very stable conducting polymers[J]. Adv Mater,1992,(4): 116.
  • 5Cui X T, Martin D C. Surface modification of neural recording microelectrodes with conducting polymers[A].32nd Annual Neural Prosthesis Workshop[C].Bethesda,MD,USA: 2001.
  • 6Cui X T. Electrochemical deposition and characterization of conducting polymer polypyrrole/PSS on multichannel neural probes[J]. Sens Actuat A:Phys, 2000,93: 8-18.
  • 7Borkenhagen M, Clemence J F, Sigrist H, et al.Three dimensional extracellular matrix engineering in the nervous system[J]. J Biomed Mater Res ,1998, 40: 392-400.

同被引文献12

  • 1Larrna T F,Reynolds J R,Qiu Y J.Polypyrrole as a Solide Electrolyte for Tantalum Capacitors[J].Synthmet,1996,79 (2):229-233.
  • 2Abraham J K,Xie Jining,Varadan V K.Smart Structures and Materials[J].2005,5763:133-138.
  • 3Reynol A F,Shetter A G.Scarring Around Cervical Epridural Stimulating Electrode[J].Neurosurgery,1983,13:63-65.
  • 4Anderson J P,Nilsson.Bioactive Silk-Like Protein Polymer on Silcon Devices[J].Proceeding of Mater Res Soc.boston:Mater Res Soc,1994,330:171-177.
  • 5Sutton S J,Vaughan A S.On the Morphology and Growth of ElectrocHemically Polymerized Polypyrrole[J].Polymer,1995,36(9):1849-1857.
  • 6Almawiawi D,Coombs N,Moskovits M.Magnetic Properties of Fe Deposited Into Anodic Aluminum Oxide Pores as a Function of Particle Size[J].J Appl Phys,1991,70:4421-4425.
  • 7Van Dyke L S,Martin C R.Electrochemical Investigations of Electronically Conductive Polymers.4.Controlling the Supermolecular Structure Allows Charge Transport Rates to be Enhanced[J].Langmuir,1990,6:1118-1123.
  • 8B.Kasemo.Biocompatibility of Titanium Implants:Surface Science Aspects[J].J Prosth Dent,1983,49:832.
  • 9尼克尔斯 J G,马丁 A R,等.神经生物学[M](第一版).北京:科学出版社,2003:9.
  • 10柳闽生,杨迈之,郝彦忠,蔡生民,李永舫.导电高聚物修饰纳米尺度TiO2多孔膜电极的光电化学研究[J].化学学报,2001,59(3):377-382. 被引量:21

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部