抗心律失常海洋新化合物C03的毒理学研究

Toxicological Researches of Anti-arrhythmic Ocean New Compound C03

研究了C0 3(C0 3是从海星中分离并经结构修饰的新化合物 )对NIH小鼠的急性毒性作用及SD大鼠 90d长期毒性作用 ,实验结果表明 :新化合物C0 3测不出其LD50 ,最大耐受量每kg体质量 >1 5g ;对大鼠 90d连续灌胃给予样品 ,在 4 5d ,90d及 14d恢复期 ,分别对大鼠多项生化指标及其重要脏器 (心、肝、脾、肺、肾、子宫、卵巢、睾丸 )进行大体和组织病理学检查 ,在本实验剂量条件下 ,均未发现毒性反应或病理性改变 ,提示新化合物C0 3无毒副作用 ,服用安全。

A new compound C03 was separated and modified from from starfish nature produe.Acute toxic test and SD mouse 90_day_toxic test of C03 showed that the LD_ 50 of C03 can't be tested,and result of the most to lerance dose is more than 1 5 g/kg by test.In of giving C03,results of many biochemical indexes and important organs(including heart,liver,spleen,lung,kidney,womb,ovary and testicle)did not show toxic reactions or pathologic changes by dissection and microscopy examinations aftr giving simple C03 for 45,90 days and withdrawing 14 days.These showed that the new compound C03 had not toxic or side effect,was safe for giving.