苯那普利治疗糖尿病肾病临床研究

Treatment of Diabetic Nephrosis Patients with Benazepril

目的 探讨苯那普利 (洛汀新 )对糖尿病肾病 (DN)患者尿蛋白排泄和肾功能的影响。方法 60例DN患者在抗糖尿病的基础上 ,加洛汀新 10～ 15mg/d ,短期观察 10～ 15周。结果 10～ 15周后 ,2 4h尿蛋白及血压明显降低 (P <0 0 1) ,尿蛋白排泄的降低与血压的下降无显著相关 ,血Cr ,BUN ,血钾 ,空腹血糖和 2 4h尿糖无明显变化。

Objective The influence of DN patient's urinary protein and renal function with Benazepril was observed in a short term.Methods 60 DN patients on basal diabetes treatment were applied Benazepril 10～15 mg/day,10～15 weeks.Results After 10～15 weeks,24 hours urinary protein quantitative estimation and blood pressure distinctly descended(P<0 01).The lowering of urinary protein was not dramaticaly correlative with blood pressure descent.Blood Cr,BUN,K +,fasting blood-glucose and 24 hours urinary glucose quantitative estimation did not obviously changed.Conclusion Benazepril had better protection to DN.