炎症性肠病患者的vWF、血小板检测及其临床意义

Detection of vWF and platelet in the patients of IBD and their clinical implications

目的 了解活动性炎症性肠病 (IBD)患者的血管内皮细胞损伤和血小板功能障碍情况。方法 采用单克隆酶联吸附法测定 2 6例活动性IBD患者及 3 1例健康对照者的血浆血管性假血友病因子 (vWF)水平 ,用全自动血细胞分析仪检测血小板计数及平均血小板体积 (MPV)。结果 IBD患者的血浆vWF∶Ag水平及血小板计数明显高于健康对照组 (P <0 0 5 ) ,而MPV显著低于健康对照组 (P <0 0 1)。结论 活动性IBD患者血管内皮细胞显著受损 ,血小板活性增强 ,血栓前状态是IBD的发病因素 ,而血vWF和MPV是活动性IBD的指标。

Objective To investigate the endothelial injury and platelet dysfunction in the patients with inflammatory bowel disease(IBD).Methods The levels of von Willebrand factor(vWF) in the plasma of 26 patients with IBD and 31 healthy individuals as controls were detected by monoclonal enzyme links immunosorbent absorption assay.The platelet counts and mean latelet volume (MPV) of patients and controls were measured by automatic hematologic analyzer.Results The levels of vWF∶Ag in the plasma and the platelet counts of the patients with IBD were higher than those in the controls ( P <0 05).The MPV in the patients was significantly lower than that in the controls ( P <0 01).Conclusions The endothelial cells were significantly damaged and the platelet activity was elevated in the patients with IBD.The prothrombotic state was aetiological factor in IBD.The vWF and MPV were useful markers of active IBD.