急性胰腺炎血清sTNF-R、IFN-γ、IL-6、IL-8、NO、NOS水平与其严重程度的研究

Relationship between the serum levels of sTNF-R,IFN-γ,IL-6,IL-8,NO,NOS in acute pancreatitis patients with its serious degrees

目的 探讨急性胰腺炎 (AP)血清可溶性肿瘤坏死因子受体 (sTNF R)、γ 干扰素 (IFN γ)、白细胞介素 6(IL 6)、白细胞介素 8(IL 8)、一氧化氮 (NO)和一氧化氮合成酶 (NOS)的临床意义。方法 分为三组 ,轻症AP(MAP)组 ,重症AP(SAP)组和对照组。在发病 3天内取外周静脉血检测 ,同期测定对照组。结果 MAP组sTNF R、IFN γ、IL 6及IL 8水平明显高于对照组 (P <0 0 5 ) ,NO及NOS水平均略高于对照组 (P >0 0 5 ) ,SAP组所有因子均高于MAP组 (P <0 0 1,P <0 0 5 )。结论上述血清因子有助于判断AP严重程度和预后 。

Objectioe To study the relationship between serum levels of sTNF R,IFN γ,IL 6,IL 8,NO,NOS in AP patients and their clinical significance.Methods Contained mild AP(MAP),severe AP(SAP) and contrast group.Specimens were examined the serum levels of sTNF R and IFN γ,NO,NOS.Results The serum levels of sTNF R,IFN γ,IL 6,IL 8,NO,NOS in SAP group were higher than that in MAP ( P <0 05),the later were also higher than that in contrast group ( P <0 05) except NO,NOS( P >0 05),which were similar to that in the contrast group.Conclusions The results show that all those serum levels have directive clinical significances to judge serious degrees and to predict the prognosis of AP.