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曲美他嗪治疗不稳定性心绞痛临床观察

Clinic outcome of patients with unstable angina pectoris treated with trimetazidine
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摘要 目的 :观察曲美他嗪治疗不稳定性心绞痛的临床疗效。方法 :观察 3 2例不稳定性心绞痛病人曲美他嗪治疗 ( 60mg/d)前后的心绞痛发作次数、硝酸甘油消耗量、运动试验结果、静息心电图、心率及血压。结果 :曲美他嗪治疗后不稳定性心绞痛病人的心绞痛发作次数、硝酸甘油消耗量、总运动时间、静息心电图较治疗前明显改善 (分别P <0 0 1) ;心率及血压无明显变化。结论 Objective: To investigate the clinic outcome of patients with unstable angina pectoris treated with trimetazidine.Methods: Number of angina attacks、nitrate consumption、treadmill exercise tests、ECG at rest、heart rate and blood pressure were observed befor and after the treatmnet of trimetazidine 60 mg/d.Results: The number of angina attacks、nitrate consumption、treadmill execise tests and ECG at rest were significantly improved after the treatmnet of trimetazidine 60 mg/d.Conclusion: Trimetazidine can bring about additional improvements in patients with unstable angina pectoris.
作者 李丽 王光公
机构地区 河南省人民医院二内科
出处 《河南医学研究》 CAS 2003年第2期136-137,共2页 Henan Medical Research
关键词 曲美他嗪 治疗 不稳定性心绞痛 临床观察 临床疗效 心率 血压 心电图 angina pectoris trimetazidine clinical study
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献8

  • 1王光公,杜习智,郑玉红.曲美他嗪治疗稳定性心绞痛临床观察[J].河南医学研究,2002,11(3):247-248. 被引量：2
  • 2Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism form fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase[J] .Cire Res.2000,86(5) :580-588.
  • 3Stanley WC, Lopaschuk GD, Hall JL, et al. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions[ J]. Cardioveac Res. 1997,33(3) :243-257.
  • 4Lopaschuk GD, Stanley WC. Glucose metabolism in the ischemic heart[ J].Circulation. 1997,95(2) :313-315.
  • 5Lu C,Dabrowski P,Fragasso G,et al. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease[J] .Am J Cardiol. 1998,82(7) :898-901.
  • 6Szwed H, Sadowski Z, Elikowski W, et al. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized,double, bling, multicentre study (TRIMPOL Ⅱ ). TRIMetazidine in POLand[ J] .Eur Heart J.2001,22(24) :2267-2274.
  • 7Manchanda SC, Krishnaswami S. Combination treatment with trimetaxidine and diltiazem in stable angina pectoris[ J]. Heart, 1997,78(4):353-357.
  • 8Polonski L,Dec I. Wojnar R,et al.Trimetazidine Limits the effects of myocardial ischaeia during percutaneous coronary angioplasty[ J].. Curz.Med Res Opin. 2002,18(7) :389-396.

二级参考文献7

  • 1[1]Kantor PF,Lucien A,Kozak R,et al.The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme a thiolase[J].Circ Res,2000,86(5):580-588.
  • 2[2]Stanley WC,Lopaschuk GD,Hall JL,et al.Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions[J].Cardiovase Res,1997,33(2):243-257.
  • 3[3]Lopaschuk GD,Stanley WC.Glucose metabolism in the ischemic heart[J].Circulation,1997,95(2):313-315.
  • 4[4]Lu C,Dabrowski P,Fragasso G,et al.Effects of trimet azidine on ischemic left ventricular dysfunction in patients with coronary artery disease[J].Am J Cardiol,1998,82(7):898-901.
  • 5[5]Detry JM,Sellier P,Pennaforte S,et al.Trimetazidine:a new concept in the treatment of angina.Comparison with propranolol in patients with stable angina.Trimetazidine European Multicenter Study Group[J].Br J Clin Pharmacol,1994,37(3):279-288.
  • 6[6]Szwed H,Sadowski Z,Elikowski W,et al.Combination treatment in stable effort angina using trimetazidine and metoprolol:results of a randomized,double-blind,multicentre study (TRIMPOL H).trim etazidine in Poland [J].Eur Heart J,2001,22(24):2267-2274.
  • 7[7]Manchanda SC,Krishnaswami S.Combination treatment with trimetazidine and diltiazem in stable angina pectoris[J].Heart,1997,78(4):353-357.

共引文献1

河南医学研究
2003年 第2期

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