中药KALⅠ号、Ⅱ号对T_(200)荷瘤小鼠肿瘤抑制作用的研究

EFFECT OF CHINESE DRUG KAL NO.Ⅰ、Ⅱ ON INHIBITING TUMOR IN MOUSE BEARING TUMOR T_(200)

目的 :探讨中药KALⅠ号、Ⅱ号对T2 0 0 荷瘤小鼠肿瘤的抑制作用。方法 :本实验采用体内动物实验方法 ,建立T2 0 0 荷瘤小鼠动物模型。通过观察给药 1 4日后小鼠瘤重来考察中药KALⅠ号、Ⅱ号的抗肿瘤活性。结果 :中药KALⅠ号在大、中、小剂量均具有明显的抑制肿瘤作用。抑瘤率分别为 5 3.6 2 % ,4 9.39% ,33.89% ,其中大剂量组疗效最佳。大、中剂量与阳性药对照组之间亦无显著差异。结论 :中药KALⅡ号在大、中剂量时具有明显的抑制肿瘤作用。抑瘤率分别为 4 4.1 3% ,2 3.2 8% ,其中大剂量组疗效更佳 .大。

Objective: To explore the inhibiting.tumor effect of the chinese drug KALNo.Ⅰ?Ⅱin mouse bearing tumor T 200 .Methods:Built mouse bearing tumar T 200 model with internal animal experiment.Investigated the antitumor activity of the Chinese drug KALNo.Ⅰ?Ⅱby obesrving the tumor weight of the mouse affer administrating the drug for 14 days.Results:KALNo.Ⅰinhibited tumor obriousby at all the three dose of large,middle and small,the ratio of inhititing tumor are 53.62%,49.39%,33.89%respectively.Compared with the positive group,both the large dose and the middle dose have no obrious differeace.KALNo.Ⅱonly at large dose and middle dose inhibited tumor obviously,the ratio of inhibiting tumor are 44.13 and 23.28% respectively.Compared with the positive group,both the large dose and the middle dose have no obrious drfference.Conclusion:The chinese drug KALNo.Ⅰ?Ⅱ has the effect of inhibiting tumor in mouse bearing tumor T 200 .