SARS病原导致人体脏器发生的病理及超微结构改变

SARS Pathogen Leading to Ultrapathological Change of Human Internal Organs

对SARS死亡患者的尸检标本进行了光镜和电镜观察。结果:SARS病原体引起人体多个脏器的超微结构发生病理变化,表现为肺泡壁增厚,肺泡腔有絮状渗出物、间质可见纤维素及少量炎细胞浸润;心肌纤维断裂,线粒体肿胀;脾和淋巴结细胞膜崩解破坏;肾小管上皮细胞坏死脱落。在病变组织中可见少量病原颗粒。提示:SARS病原引起人体的细胞免疫病理反应,引起机体多个脏器,特别是肺、心及免疫器官的损害。

To investigate the relationship between the clinical expression and ultrastructural pathology of internal organs in SARS. The autopsy specimens included lungs(8 cases) , hearts(4 cases), livers(4 cases), spleens(3 cases), kidneys(5 cases) and lymph nodes(3 cases) obtained from SARS cases. These organ samples were examined with light and electron microscope. The examination result shows: the wall of alveolus becames thicker; some of the inflammatory cells and fibrin seeped to the alveolar sac as well as lung interstitial; the fibril of cardiac muscle broke and mitochondria swelled; the lymph cells necrosis and membrane were destroyed in the spleen and lymph node. Some pathogen particles were observed in certain organs under the electron microscope. The SARS pathogen as a causative factor of the disease causes the immunopathological reaction. This reaction leads to the damage of the human body, especially to the damage of the lung, heart and immunity organs.