基于表面活性剂的纳米包膜微泡超声造影剂

SURFACTANT-BASED NANO-SHELLED MICRO-BUBBLE ULTRASOUND CONTRAST AGENT

采用声空化的方法 ,以 3种酯类表面活性剂作为微泡的纳米包膜材料进行了静脉注射微泡超声造影剂的制备研究 ,实验研究了超声功率与超声时间的选择、磷酸盐缓冲溶液 pH值对微泡产量的影响、通气方式的选择、稀释液对微泡流动性的影响、振动对微泡的影响 ,研究了微泡的保存方式 ,并对制备出的微泡超声造影剂进行了体外及动物体内造影成像效果研究 ,给出了实验犬肾脏造影灌注的结果 .

A new intravenous micro bubble ultrasound contrast agent with three ester surfactants and other additives as its nano shelled materials was prepared by sonication. Some paramemters in the process such as the selection of ultrasound power and time, the effect of the buffer pH value on the micro bubble production, the adding style of the inner gas, the effect of different diluents on the micro bubble flowing state, were studied. The preservation styles and in vitro contrast imaging of the micro bubbles were investigated. Six dogs were used to verify the in vivo contrast effect of the prepared micro bubble ultrasound contrast agent. The ultrasound contrast perfusion images of the dog's kidney were gived.