大肠癌患者血清可溶性细胞间粘附分子水平的临床意义

Clinical significance of soluble adhesion molecules in patients with colorectal cancer

目的 探讨血清可溶性细胞间粘附分子 1 (sICAM 1 )和可溶性内皮细胞白细胞粘附分子 1 (sELAM 1 )的检测在大肠癌患者中的临床意义。方法 采用双抗体夹心ELISA法检测 4 0例大肠癌、2 5例大肠良性病变及 2 0例健康体检者血清sICAM 1和sELAM 1水平 ,并比较大肠癌患者术前、术后 ,转移、无转移sICAM 1和sELAM 1水平变化。结果 大肠癌患者血清sICAM 1和sELAM 1水平明显高于良性病变患者及正常人 (P <0 .0 1 ) ;大肠癌患者术后血清sICAM 1和sELAM 1水平较术前明显下降 (P<0 .0 5 ) ;有转移的大肠癌患者血清sICAM 1水平高于无转移的患者 (P <0 .0 1 ) ,而sELAM 1水平相差无显著性 (P >0 .0 5 )。结论 血清sICAM 1和sELAM 1水平与大肠癌的发生、发展密切相关 。

Objective To investigate the clinical significance of determining serum sICAM 1 and sELAM 1 in patients with colorectal cancer.Methods The levels of sICAM 1 and sELAM 1 were tested in 40 patients with colorectal cancer,25 patients with colorectal carcinoid and 20 normal subjects by using double antibody sandwich enzyme linked immunoadsordent assay,and the changes of sICAM 1 and sELAM 1 levels in the patients with colorectal cancer pre operation and post operation,metastasis and non metastasis.Results Colorectal cancer patients showed significantly higher serum levels of sICAM 1 and sELAM 1 compared with those in healthy controls and colorectal carcinoid( P <0.01).Post operated patients showed lower levels of sICAM 1 and sELAM 1 than those of pre operation( P <0.05).The sICAM 1 levels were significantly higher in patients with metastasis( P <0.01),while the sELAM 1 levels were not significantly elevated compared with patients with non metastasis( P >0.05).Conclusion sICAM 1 and sELAM 1 may serve as a useful marker for colorectal cancer and may closely reflect its development and progress.