摘要
①目的 探讨恶性肿瘤病人手术及化疗前后T淋巴细胞亚群的变化。②方法 采用单克隆抗体间接免疫荧光法对 86例恶性肿瘤病人进行外周血T淋巴细胞亚群动态检测 ,并对部分病人化疗前后T淋巴细胞亚群检测结果进行比较。③结果 恶性肿瘤病人T淋巴细胞亚群各项指标与对照组比较均明显降低 (F =30 .59～60 3 .58,q=2 .98～ 42 .0 2 ,P <0 .0 5) ;手术后 1周与手术前比较T淋巴细胞亚群各项指标均无明显变化 (q =0 .2 4～ 2 .2 2 ,P >0 .0 5) ;手术后 3周与术前比较各项指标均有显著提高 (q =9.2 6～ 41 .81 ,P <0 .0 1 ) ,与正常人比较也有显著差异 (q=2 .98～ 1 9.36 ,P <0 .0 5)。化疗前后T淋巴细胞亚群各项指标均没有显著变化 (t=0 .81～ 1 .1 0 ,P均 >0 .0 5)。④结论 手术创伤对恶性肿瘤病人T淋巴细胞亚群有一定影响 ,并且在疾病的各个阶段均有不同程度的异常。
Objective\ To explore the changes of T cell subset in patients with malignant tumors before and after surgery and chemotherapy.\ Methods\ T cell subsets of peripheral blood were dynamically detected by monoclone antibody indirect fluoroimmunoassay in 86 patients with malignant tumors. The results of T cell subsets were compared before and after chemotherapy in part of the patients.\ Results\ Every index of T cell subset in patients was significantly lower than that in the controls ( F= 30.59- 603.58, q =2.98-42.02,P <0.05). Compared the index of T cell subset in patients before surgery and within one week after surgery, there was no significant changes ( q=0.24-2.22, P >0.05). The index of T cell subset in patients within three weeks after surgery was significantly higher than that before surgery ( q=9.26-41.81,P <0.01), and it was also significantly lower than that in the controls ( q=2.98-19.36, P <0.05). There was no difference between the patients before and after chemotherapy ( t=0.81-1.10, P >0.05). Conclusion\ The trauma of surgery may have an effect on the T cell subset in patients with malignant tumors and will show abnormality of different degrees in different stages of the diseases. Chemotherapy probably may not have any effect on it.
出处
《齐鲁医学杂志》
2003年第2期131-132,共2页
Medical Journal of Qilu
