枢丹防止儿童斜视矫正术后恶心呕吐的临床观察

Effect observation of Shudan on preventing postoperative nausea and vomiting after pediatric strabotomy

目的 评价儿童斜视矫正手术中应用3型5-羟色胺受体拮抗剂—枢丹防止术后恶心呕吐的效果。方法将40例斜视矫正手术患儿随机分为两组,A组术中静滴枢丹2 mg。B组未用任何止吐药。两组患儿术中均为氯胺酮麻醉。记录用药前后平均动脉压(MAP)、心率(HR)、脉博血氧饱和度(SPO_2)的改变及术后24小时内恶心呕吐的发生率。结果 A组术后恶心呕吐的发生率明显低于B组(P<0.05),而用药前后患儿平均动脉压、心率及脉博血氧饱和度差异均无显著意义(P>0.05)。结论 枢丹能有效防止儿童斜视矫正术后的恶心呕吐,而且对患儿生命体征影响很小。

Objective To observe the effects of Shudan on preventing postoperative nausea and vomiting (PONV) after pediatric strabotomy. Methods 40 children were randomly divided into two groups. Shudan was used during operation in Group A , while none of anti-vomiting agent was used in Group B, General anesthesia were used in all patients. The rates of postoperative nausea and vomiting in 24 hours were recorded in both groups, MAP, HR,SPO2 were measured before and after administration. Results The rate of postoperative nausea and vomiting in Group A was significantly lower than that in Group B ( P < 0.05). Conclusion Shudan can effectively prevent postoperative nausea and vomiting (PONV) after pediatric strabotomy and is smooth in patients.