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神经干细胞移植对帕金森病模型小鼠行为的影响 被引量：4

Effects of neural stem cells transplantation on the behavior of Parkinson's disease mice
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摘要 目的评价神经干细胞移植对帕金森病 (PD)模型小鼠行为缺陷的改善作用。方法采用自发运动、Morris水迷宫和转杆实验对小鼠的行为进行评价。结果与对照组相比 ,PD模型小鼠的自发运动次数明显减少 ,水迷宫寻台潜伏期延长 ,转杆时间缩短。经单侧和双侧纹状体神经干细胞移植后 2周、4周和 8周 ,PD模型小鼠的自发运动次数明显增加 ,水迷宫寻台时间显著缩短 ,转杆时间延长。结论神经干细胞移植能够有效改善PD模型小鼠的行为缺陷。 ObjectiveTo observe the effects of neural stem cells transplantation on the behavioral deficits of Parkinson's disease mice.MethodsSpontaneous movement,Morris Water Maze and Rotarod were adopted to evaluate the behavioral changes.ResultsCompared with the control,the time of spontaneous movement was decreased,the latency of Water Maze was lengthened,and the time of Rotarod was shortened in the Parkinson's disease(PD) mice. These deficits were improved 2, 4 and 8 weeks after unilateral and bilateral transplantation of neural stem cells.ConclusionsThe transplantation of neural stem cells can improve the behavioral deficits in the PD mice.
作者 郭安臣 李学坤 澹台冀澄 孔令娜 左萍萍
机构地区 中国医学科学院
出处 《中国康复理论与实践》 CSCD 2003年第7期399-400,共2页 Chinese Journal of Rehabilitation Theory and Practice
关键词 神经干细胞移植 帕金森病模型 行为 小鼠 neural stem cells transplantation Parkinson's disease behavior mice
分类号 R318.5 [医药卫生—生物医学工程] R742.5 [医药卫生—神经病学与精神病学]
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参考文献11

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二级参考文献28

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共引文献15

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二级引证文献22

中国康复理论与实践
2003年 第7期

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