急性脑血管病患者血清甲状腺素和泌乳素变化及其临床意义

The change and its significance of serum thyroxin and prolactin in patients of acute cerebrovascular disease

目的 观察急性脑血管病(ACVD)患者血清甲状腺素及泌乳素(PRL)含量的变化。方法 通过放射免疫法检测100例ACVD患者血清三碘甲状腺原氨酸(T3)、甲状腺素 (T4)、促甲状腺激素 (TSH)、反T3(RT3)及泌乳素(PRL)的含量 ,并与51例正常人进行对照。结果 ACVD患者血清T3、T4均明显低于对照组(p<0.01) ,血清TSH、RT3、PRL均显著高于对照组(p<0.01)。出血性中风组上述甲状腺激素及泌乳素变化均高于缺血性中风组(p<0.05) ,且各项指标改变与病变大小及部位有关。 结论 血清甲状腺素及泌乳素有助于判断ACVD病情 ,估计预后 ,对治疗有一定的指导意义。

Objective To objective the change of serum thyroxin and prolactin in patients of acute cerebrovascular disease(ACVD). Methods Serum triiodothyronine(T3),thyroxin(T4),thyroid-stimulating hormone(TSH),reverse T3and prolactin(PRL)were detected by radio-immunity assay in100patients of ACVD and51normal people and were compared with each other. Results As compared to those of normal people,in ACVD patients,the levels of serumT3and T4were significantly lower(P<0.01),the levels of serumTSH,RT3and PRLwere all significantly higher(P<0.01).The levels of kinds of serumthyroid hormone and PRLin patients of hemorrhagic stroke group were higher than those in patients of ischemia stroke group and the change of above-mentioned makers were related with lesion size and position. Conclusion Serumthyroxin and prolactin were helpful for judging state of ACVD and estimating prognosis and had some instructional therapy significance.