138株致肺炎的鲍曼不动杆菌耐药性研究

Antimicrobial resistance of 138 strains of Acinetobacter baumanni causing nosocomial acquired pneumonia

目的 了解某医院鲍曼不动杆菌的耐药情况,以指导临床合理用药。方法 采用API20NE系统进行细菌鉴定,琼脂扩散法进行药敏试验。结果 从肺部感染患者的疾标本中分离出的138株鲍曼不动杆菌对各类抗菌药物均有不同程度耐药,其中对氨曲南、氨苄西林耐药率达90％以上;对亚胺培南的耐药率最低,为0.7％,其次为头孢哌酮/舒巴坦10.1％,头孢吡肟10.9％,阿米卡星15.2％;头孢他啶和头孢噻肟有不少菌株处于中介范围。结论 鲍曼不动杆菌所致肺炎具多重耐药,治疗困难;应根据药敏结果用药,减少抗菌药物滥用,以免造成严重的医院感染流行。

Objective To study the antimicrobial resistance of Acinetobacter baumanni in a hospital, and provide guidelines for antimicrobial agents choice. Methods Bacteria identification was made with API20NE System and antimicrobial susceptibility tests were done by disc agar diffusion test. Results One hundred and thirty- eight strains of Acinetobacter baumanni which cause the lung infection were isolated from clinical samples, resistant rate to aztreonam and ampicillin was about 90 %, resistant rate to imipenem was the lowest (0.7%), followed by cefoperazone/sulbactam (10.1%), cefepime (10.9%) and amikacin (15.2%), the other drugs had different antimicrobial resistance. Conclusion The lung infection caused by Acinetobacter baumanni has multiply antimicrobial resistance, and is difficult to treat; the overuse of antimicrobial agents should be reduced to prevent the prevalence of infection.