青少年强直性脊柱炎早期年龄、身高、体重与L_(1-4)BMC、L_(1-4)BMD相关性初步分析

Effects of age,height and weight on L_(1-4)BMC and L_(1-4)BMD in early adolescent ankylosing spondylitis

目的 研究青少年强直性脊柱炎 (Ankylosingspondylitis,AS)早期年龄、身高、体重与腰椎L1 -4骨矿含量 (L1 -4BMC)、腰椎L1 -4骨密度 (L1 -4BMD)的相关性。方法 选择男性青少年AS早期病例 31例。应用DPX -IQ双能X线骨密度仪 (DEXA)检测L1 -4BMC和L1 -4BMD ,分析年龄、身高、体重与L1 -4BMC、L1 -4BMD的关系。结果年龄、身高、体重、L1 -4BMC、L1 -4BMD的测定值分别为 (1 7 5 6± 2 0 1 )岁、 (1 6 8 5 2± 8 5 9)cm、 (5 6 1 3±1 2 72 )kg、 (5 2 1 6± 1 2 1 7)g、 (0 971 1± 0 1 392 ) g/cm2 。L1 -4BMC与身高、体重和年龄呈正相关 (R =0 786 ,Radj2 =0 5 75 ,P <0 0 0 0 1 ) ,其中身高和体重是主要相关因素 (R =0 74 7,Radj2 =0 5 2 6 ,P <0 0 0 0 1 )。年龄、身高和体重因素中仅体重因素进入L1 -4BMD回归方程 (R =0 6 5 7,Radj2 =0 4 1 2 ,P <0 0 0 0 1 )。结论 身高和体重与L1 -4BMC相关 ,体重与L1 -4BMD相关。

Objective To investigate the correlations between age,height,weight and lumbar 1-4 bone mineral content (L 1-4 BMC),L 1-4 areal bone mineral density (L 1-4 BMD) in early adolescent ankylosing spondylitis.Methods Thirty-one male adolescent outpatients with early AS were included.L 1-4 BMC and L 1-4 BMD were assessed at the lumbar 1-4 spine using dual-energy X-ray absorptiometry and values of age,height and weight were obtained.Correlation and multiple regression analyses were performed.Results The values of age,height,weight,L 1-4 BMC and L 1-4 BMD were 17 56±2 01y,168 52±8 59cm,56 13±12 72kg,52 16±12 17g?0 9711±0 1392g/cm 2,respectively.Multiple regression revealed that the age,height and weight were significantly positively correlated to L 1-4 BMC(R=0 786,Radj 2=0 575,P<0 0001).Moreover,height and weight played major roles in correlation with L 1-4 BMC(R=0 747,Radj 2=0 526,P<0 0001).Moreover,good correlation was identified between weight and L 1-4 BMD(R=0 657,Radj 2=0 412,P<0 0001).Conclusion These results indicate that height and weight significantly correlate well with L 1-4 BMC,and weight essentially contributes to linear correlation with L 1-4 BMD in early adolescent AS.Height and weight therefore play important roles in characterization of bone mass and density in early adolescent AS.