病毒性心肌炎及扩张型心肌病患儿巨细胞病毒的检测及意义

Detection of human cytomegalovirus and its clinical significance in children with viral myocarditis and dilated cardiomyopathy

目的 探讨人巨细胞病毒 (HCMV)与病毒性心肌炎、扩张型心肌病之间的关系。方法 采用ELISA法对 5 8例病毒性心肌炎 (VM组 )、 1 0例扩张型心肌病 (DCM组 )患儿及 6 5例非心血管病患儿 (对照组 )进行血CMV -IgM检测 ,同时采用免疫组化试管法检测尿液中抗CMV -SPTM阳性细胞。结果 3组患儿血CMV -IgM阳性率及尿CMV -SPTM阳性率间的差别均有显著性意义 (P <0 0 5 ) ,而VM与DCM组患儿血CMV -IgM阳性率及尿CMV -SPTM阳性率间的差别均无显著性意义 (P >0 0 5 )。结论 巨细胞病毒与病毒性心肌炎、扩张型心肌病的发病有关。

Objective To explore the relationship between human cytomegalovirus(HCMV) and viral myocarditis,dilated cardiomyopathy.Methods Blood sample taken from 58 cases of clinically diagnosed viral myocarditis,10 cases of clinically diagnosed dilated cardiomyopathy and 65 cases without heart disease were detected for CMV-IgM by Enzyme Linked Immunosorbant Assay(ELISA),urine sample of theirs were detected for anti-CMV-SP TM by immune histochemistry in test tube at the same time.Results The positive rates of blood and urine in viral myocarditis,dilated cardiomyopathy were higher than that of contrast group(P<0 05).Conclusion The results suggested that HCMV is related to the etiology of viral myocarditis and dilated cardiomyopathy.