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细胞防护剂WR-2721研究进展 被引量：1

Advances in research of the cytoprotector WR-2721
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摘要 WR-2721(amifostine)是一种广谱的细胞保护剂,在体内通过其活性形式WR-1065保护正常细胞,减轻放、化疗毒副作用,促进造血细胞恢复,使患者可以耐受大剂量放、化疗。WR-2721可能成为高恶性和耐药性肿瘤治疗新策略之一。 WR-2721(amifostine)is a broad-spectrum cytoprotector.Its active metabolite-WR1065can protect normal cell,reduce the toxicities of radiotherapy and chemotherapy and improve hematoiogic cell.As a result,the patients may tolerate the high dose of chemo-radiotherapy.WR-2721may be a new way on the therapies of the high-advanced and the multidrug resistant tumor.
作者 顾宏涛 田琼 杨岚 郑秀龙
机构地区 第四军医大学西京医院血液科（陕西西安 第四军医大学基础部教学实验中心 第四军医大学西京医院血液科 第二军医大学海军医学系
出处 《国外医学（放射医学核医学分册）》 2003年第3期135-137,共3页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 细胞防护剂 WR-2721 研究进展 肿瘤 治疗 放射疗法 化学疗法 辐射防护 WR-2721(amifostine) radiotherapy chemotherapy radiation protection
分类号 R96 [医药卫生—药理学]
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参考文献14

  • 1Savoye C, Swenberg C, Hugot S, et al. Thiol WR-1065 and disulfide WR-33278, two metabolites of the drug Ethol(WR-2721), protect DNA against fast neutron induced strand breakage [J]. Int J Radiat Biol, 1997, 71:193-202.
  • 2North S, EI-Ghissassi F, Verdaegh G, et al. The cytoprotective aminothiol WR-1065 activates p21 wat-1 and down regulates cell cycle progression through a p53-dependent pathway[J].Oncogene, 2000, 19(9):1206-1214.
  • 3Snyder RD, Grdina DJ. Further evidence that the radioprotectibve aminothiol, WR-1065, cataly inactivates mammalian topoisomerase 2 [J]. Cancer Res, 2000, 60:1186-1188.
  • 4Momm F, Bechtold C, Rudat V, et al. Alteration of radiation-induced hematotoxicity by manifesting [J]. Int J Radiat Oncol Biol Phys, 2001, 51(4): 947-951.
  • 5Fulda S, Fiehtner I, Hero B, et al. Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients [J]. Med Pediatr Oncol, 2001, 36(1):199-202.
  • 6Antonadou D, Coliarakis N, Synodinou M, et al. Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer [J]. Int J Radiat Oncol Biol Phys, 2001 , 51(4): 915-922.
  • 7Jahnukainen K, Jahnukainen T, Salmi TY, et al. Amifostine protects against early but not late toxic effects of doxorubicin in infant rats [J]. Cancer Res, 2001, 61: 6423-6427.
  • 8Koukourakis MI, Romanidis K, Froudarakis M, et al. Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection [J]. Br J Cancer, 2002, 87(4): 385-392.
  • 9Michieli M, Michelutti A, Damiani D, et al. Amifostine does not inhibit the toxic effects of anthracycline derivates or mitoxantrone on MDR tumor cell lines [J]. Leuk Lymphoma,2001,42(4): 721-729.
  • 10Galanopoulos A, Kritikou-Griva E, Gligori J, et al. Treatment of patients with myelodysplastic syndrome with manifesting [J]. Leuk Res, 2001, 25(8): 665-671.

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国外医学（放射医学核医学分册）
2003年 第3期

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