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CD40L、IL-10和IL-17的辐射防护作用 被引量：2

The role of CD40L、IL-10 and IL-17 in radioprotection
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摘要 CD40L(CD40配体)作为重要的共刺激分子,与CD40(白细胞分化抗原40)相互作用参与机体细胞和体液免疫调节,并在免疫应答中起着极其重要的作用。IL-17(白细胞介素17)可诱导IL-6(白细胞介素6)和G-CSF(粒细胞集落刺激因子)等细胞因子的产生,从而刺激造血祖细胞(CD34+)增殖、分化。IL-10(白细胞介素10)可干扰共刺激分子的上调,抑制免疫刺激因子(如IL-12)的产生,用抗IL-10单抗可阻断紫外线诱导的免疫抑制。简要介绍了CD40L、IL-17和IL-10在辐射防护中的作用。 CD40L/CD40interaction is central to the control of thymus-dependent humoral immunity and cell mediated immune responses.IL-17has been shown to induce the production of IL-6and G-CSF,which can induce proliferation and differentiation of CD34 + hematopoietic progenitors.IL-10can interfere with up-regulation of costimualtory molecules,thus suppressing the production of costimulatory cytokines,such as IL-12.IL-10has been implicated as an essential me-diator in the induction of systemic immune suppression following ultraviolet(UV)exposure.Treating UV-irradiated mice with anti-IL-10blocks the induction of immune suppression.
作者 李廷 张学光 强亦忠
机构地区 苏州大学生物技术研究所（苏州 苏州大学生物技术研究所
出处 《国外医学（放射医学核医学分册）》 2003年第3期132-134,共3页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金 国家863计划资助项目(2001AA215341)
关键词 辐射防护 CD40L IL-10 IL-17 相互作用 共刺激分子 CD40ligand interleukin-10 interleukin-17 radioprotection
分类号 R14 [医药卫生—公共卫生与预防医学]
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参考文献10

  • 1Anne S, Julie D, Abdel EA, et al. CD40-ligand stimulated myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells [J]. Blood, 2000,95: 3758-3764.
  • 2Ishikawa F, Nakano H, Seo A, et al. Irradiation up-regulates CD80 expression through induction of tumor necrosis factor-alpha and CD40 ligand expression on B lymphoma cells[J]. Immunology, 2002, 106(3): 354-362.
  • 3Fang W, Nath KA, Mackey MF, et al. CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation[J]. Am J Physiol, 1997, 272(3 Pt 1):C950-C956.
  • 4Jovcic G, Bugarski D, Petakov M, et al. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow[J]. Growth Factors, 2001, 19(1): 61-71.
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  • 6Yoshida Y, Kang KF, Berger M, et al. Monocyte induction of IL-10 and down-regulation of IL-12 by iC3b deposited in ultraviolet-exposed human skin [J]. J Immunol, 1998,161: 5873-5879.
  • 7Shreedhar V, Giese T, Sung VW, et al. A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression [J]. J Immunol, 1998, 160: 3782-3789.
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国外医学（放射医学核医学分册）
2003年 第3期

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