1,4-二氢-2,6-二甲基-4-(2-硝基苯基)-3,5-吡啶二甲酸甲异丁酯的合成

Study on the Synthesis of 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxlic Acid Isobutyl Methyl Ester

1,4 二氢 2,6 二甲基 4 (2 硝基苯基) 3,5 吡啶二甲酸甲异丁酯为一抗高血压新药,作者报道了其三步法的合成方法,并对Hanstzch合成法中制备邻硝基苯亚甲基乙酰乙酸异丁酯的方法进行了改进,反应时间缩短,得率提高至58%.对产物分子结构采用元素分析、红外光谱(IR)、核磁共振氢谱(1H NMR)及碳谱(13C NMR)进行了鉴定.

In this paper, an improved threesteps method for synthesis of the titled compound with the hypertension diminishing function was reported. It is a very convenient and useful synthesis method as the reaction time could be shortened and the yield could be improved. The structure of the final product was confirmed by elemental analysis,IR,1HNMR, and 13CNMR.