头孢吡肟治疗胸科术后重症肺部感染疗效分析

Clinical observation of cefepime in treating severe pulmonary infections following thoracic surgery.

目的观察头孢吡肟治疗胸科术后重症肺部感染的疗效及安全性。方法 19例胸科术后重症肺部感染患者采用头孢吡肟治疗 ,剂量 1g ,每 8小时 1次 ,静脉注射 ,疗程 5～ 7天 ,结果总有效率为 89.4 % ,细菌阴转率为 84 .6 % ,细菌清除率为 93.5 % ,无不良反应。 31株致病菌作药物敏感试验 ,头孢吡肟的敏感率为 10 0 % ,与泰能抗菌活性相似 ,较头孢唑啉、头孢哌酮及环丙沙星的敏感率高。结论头孢吡肟治疗胸科术后重症肺部感染安全、有效。

Objective To observe the therapeutic effect and safety of cefepime in treating severe pulmonary infections following thoracic surgery. Methods 19 cases of severe pulmonary infections following thoracic surgery were treated with 1g cefepime, once every 8 hours for a course of 5 7 days. Results The overall effect rate was 89.4%, bacteria negative converting rate was 84.6%, and bacteria clearance rate was 93.5%. No side effect related to medicine occurred. The sensitivity rate of cefepime to medicine was 100% in the medicine sensitivity to medicine test of 31 bacterial strains. Compared with the anti bacterial activity of Taineng, cefepime was the same as jaineny more sensitive than cefazolin and cefoperazone as well as ciprofloxacin. Conclusion Cefepime is an effective agent for severe pulmonary infections following thoracic surgery.