双八面体蒙脱石防治新生儿高胆红素血症81例

Clinical Observation on 81 Cases of Neonatal Jaundice Treated with Dioctahedral Smetctite

目的 :探讨双八面体蒙脱石对新生儿高胆红素血症 (新生儿黄疸 )的影响。方法 :新生儿 14 3例 ,采用单盲分组 ,治疗组 81例正常足月新生儿 ,出生后lh内开始喂奶 ,同时口服双八面体蒙脱石 1.0g ,q 8h ,连用 7d ,用药期间每隔 1d用新生儿黄疸比色板查胆红素 1次 ,至肉眼黄疸消失 ;对照组 62例正常新生儿 ,不用双八面体蒙脱石 ,每隔 1d查胆红素 1次。结果 :治疗组发生黄疸≥Ⅲ级 16.0 % (13 81) ,对照组 3 3 .9% (2 1 62 ) ,两组比较差异有显著性 (χ2 =5 .2 2 ,P <0 .0 5 ) ;治疗组黄疸时间缩短 (χ2 =3 .3 5 ,P <0 .0 1) ,无黄疸的发生率较对照组高 (χ2 =5 .97,P <0 .0 5 )。结论 :双八面体蒙脱石可以有效干预新生儿黄疸的发生、发展 ,降低新生儿黄疸发生率。

Objective:To study the effect of dioctahedral smectite on neonatal jaundice. Method:143 newborn babies were divided into two groups by single blind method. The treatment group (81 cases) was given milk an hour after they were born, and were given dioctahedral smectite orally 1.0 g every 8 hours for 7 days. During the period of drug administration bilirubin was tested with shade guide once every other day until macroscopic jaundice disappeared. The control group (62 cases) were not given the drug, and bilirubin was tested once every other day. Results:In the treatment group, 13 of 81 cases (16.0%) had neonatal jaundice, and in the control group, 21 of 62 cases (33.9%) had neonatal jaundice. Comparison of the two groups showed a remarkable difference (χ 2=5.22, P <0.05). In the treatment of group, the druation of jaundice was shortened, and the rate for won-occurrence of jaundice was higher than that in the control group(χ 2=5.97, P <0.05). Conclusion:Dioctahedral smectite may effectively intervene the occurlence and development of neonatal jaundice, and prevent bilirubin encephalopathy in the newborn.