期刊文献+

CLINICAL CHARACTERISTICS AND BASIC RESEARCH DEVELOPMENT OF PEUTZ- JEGHERS SYNDROME

CLINICAL CHARACTERISTICS AND BASIC RESEARCH DEVELOPMENT OF PEUTZ- JEGHERS SYNDROME
下载PDF
导出
摘要 To improve clinical knowledge of Peutz- Jeghers syndrome. Methods. Eight patients with Peutz- Jeghers syndrome from 1984 to 1998 in our hospital were retrospectively reviewed and analyzed in the present study. Result. The result of this analysis showed that there were 4 patients appeared with family histories of Peutz- Jeghers syndrome. All of the included patients admitted to the hospital with various complications, and eventually received surgical interventions for these complications, among which, 6 of them had intestinal obstructions mostly (5/6) due to small bowel intussusception, and 2 of them suffered with hemafecia. Post- operative recoveries were generally satisfactory with zero mortality. Conclusion. Peutz- Jeghers syndrome is an uncommon digestive dominant hereditary disease. The diagnosis of it with history, symptoms, signs, and proper examinations usually is not difficult. Surgical interventions are necessary once complications occur.
出处 《Chinese Medical Sciences Journal》 CAS CSCD 2001年第1期49-51,共3页 中国医学科学杂志(英文版)
关键词 SYNDROME PIGMENTATION POLYPOSIS LKB1 gene 粘膜黑斑-肠系肉综合症 临床表现 诊断 手术治疗 LKB1基因
  • 相关文献

参考文献7

  • 1Thomas J. Mcgarrity,Laurie P. Peiffer,Melvin L. Billingsley.Overexpression of Epidermal Growth Factor Receptor in Peutz-Jeghers Syndrome[J].Digestive Diseases and Sciences.1999(6)
  • 2A. Hemminki.The molecular basis and clinical aspects of Peutz-Jeghers syndrome[J].Cellular and Molecular Life Sciences.1999(5)
  • 3Su GH,Hruban RH,Bansal RK,et al.Germline and somatic mutations of STK11/ LKB1 Peutz- Jeghers gene in pancreatic and biliary cancers[].American Journal of Pathology.1999
  • 4Markie D,Hamminki A,Tomlinson I.A serine/ threonine kinase gene defect in Peutz- Jeghers syndrome[].Nature.1998
  • 5Guldberg P,Thor Straten P,Ahrenkiel V.Somatic mutation of the Peutz- Jeghers syndrome gene, LKB1/ STK11, in malignant melanoma[].Oncegene.1999
  • 6Westerman AM,Entius MM,de Baar E.Peutz- Jeghers syndrome: 78- year follow- up of the original family[].The Lancet.1999
  • 7Boardman LA,Thibodeao SN,Schaid DJ.Increased risk for cancer in patients with the Peutz- Jeghers syndrome[].Annals of Internal Medicine.1998

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部