苯胺与氨基甲酸甲酯合成苯氨基甲酸甲酯反应研究

Studies on Synthesis of Methyl N-Phenylcarbamate by Reaction of Aniline and Methyl Carbamate

以无水氯化锌为催化剂 ,考察了温度、时间、催化剂含量及原料配比等条件对合成反应的影响 ,确定了最优化反应条件 ,并初步探讨了反应机理 .最佳反应条件下 MPC收率可达 89.90 % ,选择性为 99.76 % .

In the presence of methanol, a new non-phosgene route for the preparation of methyl N-phenylcarbamate(MPC) was studied based on the reaction between aniline and methyl carbamate. The effects of reaction temperature, reaction time, catalyst content and the molar ratios of aniline to methyl carbamate and methanol on the reaction were studied, and the reaction mechanism over zinc chloride catalyst was proposed. Under the optimum reaction conditions, the MPC yield reached 89.90% and selectivity of MPC is 99.76%.