PHBV/Sol-gel Bioglass多孔材料在模拟生理溶液中的化学反应研究

Chemical Reaction of PHBV/Sol-gel Bioglass Foams for Born Tissue Engineering in Simulated Body Fluid

3-羟基丁酸 -co-3-羟基戊酸共聚物 (PHBV) /生物活性玻璃 (SGBG)是一种用于骨和软骨组织工程支架的新型多孔复合材料 ,本文探讨了 PHBV/ SGBG在模拟生理溶液中的一系列化学反应 ,以及多孔材料在模拟生理溶液中浸泡后的成分和结构变化 .研究结果表明 ,在 SBF溶液中浸泡后 ,SGBG与 SBF溶液的离子交换反应和 PHBV的降解反应使 SBF溶液的离子浓度发生变化 ,并在 PHBV/ SGBG表面形成了结晶态类骨碳酸羟基磷灰石 .

A new kind of porous composites prepared from poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) and sol gel bioactive glass(SGBG) are used for born tissue engineering scaffolds. In this work, the chemical reaction and in vitro degradation of PHBV/SGBG porous materials was assessed in simulated body fluid(SBF). The changes in components and structures of the porous materials were investigated before and after immersion in SBF. It was found that the ion concentrations of SBF changed with immersing time because of ion exchange reaction and degradation reaction of PHBV/ SGBG in SBF solution. FTIR and XRD analysis indicated that hydroxyl carbonate apatite(HCA) had formed on the surface of PHBV/SGBG after the porous scaffold was exposed to SBF solution for 12 h.